On the evidence of pre-season testing, the quadruple champion and his Red Bull team are up against it as the sport braces for an unpredictable new hybrid turbo era in Melbourne.
"Right now it is not an easy situation, but there is no reason to hang the head," said the 26-year-old German, who is bidding to become only the second driver after compatriot Michael Schumacher to win five titles in a row, as Red Bull wrapped up a troubled final test in Bahrain.
"When I listen to some media we are right in the middle of a huge disaster...but we will fight through it. Everybody in the team - including me - is ready to fight," Vettel told the formula1.com website.
The glamour world of grand prix racing is in the throes of a revolution, one that will be televised around the world, and Vettel is a young king whose throne is most definitely threatened in what could be a rollercoaster year.
Success-starved rivals can sense their time has come, spurred on by rare signs of weakness from the once dominant team.
The technical change is the biggest most of the sport's engineers and mechanics have ever seen thanks to the introduction of a new turbocharged V6 engine with energy recovery systems.
In this brave new world, Red Bull's preparations have been little short of shocking with neither Vettel - who won the last nine races of 2013 and has not been beaten since July - nor his new and ever-smiling Australian team mate Daniel Ricciardo completing a race simulation.
All the Renault-powered teams have struggled to log as much mileage as their Mercedes and Ferrari rivals - Cosworth having now disappeared as an engine supplier - after experiencing problems bedding in the new power unit.
Reliability is a key concern for all teams, and the early races could be full of surprises with fuel economy coming to the fore and drivers playing a game of hare and tortoise to get to the finish.
The big question is how quickly Red Bull will be able to overcome their problems and whether testing is an accurate reflection of what will come when the lights go out in Melbourne.
Lewis Hamilton, whose Mercedes team are already the early favourites, expects Red Bull to be firing on all cylinders sooner than might be expected.
"They look like they have a stunning car, and usually the more beautiful it is the faster it is so I'm sure they've got a pretty quick car this year," said the Briton who won his 2008 title with McLaren.
"Once they get the engine sorted, or the systems that they might be struggling with, I think they'll - as always - be very hard to beat."
Mercedes-powered Williams - who have signed a rejuvenated Brazilian Felipe Massa from Ferrari to replace Venezuelan Pastor Maldonado - have also looked strong in testing after scoring just five points in a dismal 2013.
Ferrari, reunited with 2007 champion Kimi Raikkonen in a lineup of champions with Fernando Alonso, have kept their cards close to their chest but the engine has looked reliable.
Expect sparks between those two fire and ice characters, the first champions Ferrari has paired since 1954, if the car proves to be a championship contender.
The same applies to Mercedes, where Hamilton and Nico Rosberg's friendship could be sorely tested.
Nothing, however, can be taken for granted.
"We have seen cars struggle to do a race distance in pre-season testing but then finish the first race on the podium. We have seen it countless times and it can happen again," Mercedes engine chief Andy Cowell told autosport.com.
"Melbourne is a very exciting step into this new world of hybrid F1. I really don't know how it is going to unfold."
The sport will have three young rookies making their debuts - Denmark's Kevin Magnussen at McLaren, 19-year-old Russian Daniil Kvyat at Toro Rosso and Sweden's Marcus Ericsson at Caterham - while others have said farewell.
Australian Mark Webber has left Red Bull to race sportscars for Porsche while Britain's Paul di Resta has returned to the German Touring Car championship (DTM) after being dropped by Force India and failing to find a seat.
Lowly Caterham have shed Frenchman Charles Pic and Dutchman Giedo van der Garde and delighted Japanese fans by bringing back the crowd-pleasing Kamui Kobayashi.
On the management side, three of the 11 principals have changed since the end of last season while even commercial supremo Bernie Ecclestone's future is clouded by an impending trial in Germany on bribery charges.
Ross Brawn has left Mercedes, where Toto Wolff and Paddy Lowe now share his responsibilities, while Martin Whitmarsh has been ousted by returning predecessor Ron Dennis at McLaren after a 2013 season without a podium finish.
Frenchman Eric Boullier has switched from Lotus to McLaren, where he will effectively run the team at races.
The 19-race calendar has a new look and, controversially, the novelty of double points on offer for the finale in Abu Dhabi in a bid to prevent the title being wrapped up too early.
India and South Korea have been dropped while Russia makes its debut with a race in Winter Olympic host city Sochi and Austria returns after a 13-year absence.
That race at the bucolic Spielberg track in June will be a home one for Red Bull. Whether Vettel will be in a position to win it remains to be seen.